This is because of a change in base R https://github.com/wch/r-source/blob/9ad27a744572fca453665e97110ded41a2680a57/doc/NEWS.Rd#L257
It can be reproduced by using a recent version R-4-1. Looking at your code, I guess it is at https://code.bioconductor.org/browse/IsoCorrectoRGUI/blob/master/R/IsoCorrectionGUI.R#L30 that things start to run into trouble -- probably instead you want to create a 'package local' environment, e.g., isoCorrectionGUIEnvironment <- new.env() as the very first line in this file, and use that for storing these variables. Martin On 5/4/21, 12:36 AM, "Bioc-devel on behalf of Christian Kohler" <bioc-devel-boun...@r-project.org on behalf of christian.koh...@ur.de> wrote: Hello BioC community, I am the maintainer of the IsoCorrectoRGUI package. Starting with April 30th, problems are reported in the Multiple platform build/check report for BioC3.13 (Linux, Windows Server as well as macOS) though IsoCorrectoRGUIs code base did not change since end of October 2020. The relevant part of the error message is shown below: * checking examples ... ERROR Running examples in ‘IsoCorrectoRGUI-Ex.R’ failed The error most likely occurred in: > base::assign(".ptime", proc.time(), pos = "CheckExEnv") > ### Name: IsoCorrectionGUI > ### Title: Graphical User Interface for IsoCorrectoR > ### Aliases: IsoCorrectionGUI > > ### ** Examples > > > IsoCorrectionGUI() Error in baseEnvRef$continueIsoCorrection <- TRUE : cannot add binding of 'continueIsoCorrection' to the base environment Calls: IsoCorrectionGUI -> initGUI Execution halted Frankly speaking, at the moment I have no clue why the CHECK procedure fails from one day to the next. Does this reflect a conflict with R 4.1.0 alpha internals? Any insight would be greatly appreciated as the deadline for passing R CMD check is in a couple of days. If anyone knows why this could be happening or if it is likely to sort itself in the next build please let me know. Thanks, Christian _______________________________________________ Bioc-devel@r-project.org mailing list https://stat.ethz.ch/mailman/listinfo/bioc-devel _______________________________________________ Bioc-devel@r-project.org mailing list https://stat.ethz.ch/mailman/listinfo/bioc-devel