> GenomeInfoDb::Seqinfo(genome='hg19')
Error in file(file, "rt") : cannot open the connection
> sessionInfo()
R version 3.3.1 (2016-06-21)
Platform: x86_64-apple-darwin15.5.0 (64-bit)
Running under: OS X 10.12.1 (Sierra)

locale:
[1] en_US.UTF-8/en_US.UTF-8/en_US.UTF-8/C/en_US.UTF-8/en_US.UTF-8

attached base packages:
[1] stats4    parallel  stats     graphics  grDevices utils     datasets 
[8] methods   base     

other attached packages:
[1] GenomeInfoDb_1.10.0 IRanges_2.8.0       S4Vectors_0.12.0   
[4] BiocGenerics_0.20.0

> On Nov 3, 2016, at 08:19, Vincent Carey <st...@channing.harvard.edu> wrote:
> 
> sessionInfo()?
> 
> On Thu, Nov 3, 2016 at 5:13 AM, Raymond Cavalcante <rcava...@umich.edu 
> <mailto:rcava...@umich.edu>> wrote:
> Hello,
> 
> Sometime yesterday calls like GenomeInfoDb::Seqinfo(genome = 'hg19') stopped 
> working with the error:
> 
> > Error in file(file, "rt") : cannot open the connection
> 
> From the documentation, that call relies on fetchExtendedChromInfoFromUCSC() 
> and requires an internet connection, which I had and continue to have. I'm 
> not really sure how to deal with this problem because the goldenPath link 
> still works 
> (http://hgdownload.cse.ucsc.edu/goldenpath/hg19/database/chromInfo.txt.gz 
> <http://hgdownload.cse.ucsc.edu/goldenpath/hg19/database/chromInfo.txt.gz> 
> <http://hgdownload.cse.ucsc.edu/goldenpath/hg19/database/chromInfo.txt.gz 
> <http://hgdownload.cse.ucsc.edu/goldenpath/hg19/database/chromInfo.txt.gz>>), 
> so something else is broken...
> 
> Oddly, calls to rtracklayer::import.bed() that specify a genome work. I don't 
> have any BSgenome packages installed where I'm running it, and from the 
> documentation for genome, "An attempt will be made to derive the ‘seqinfo’ on 
> the return value using either an installed BSgenome package or UCSC, if 
> network access is available." So I would guess that rtracklayer::import.bed() 
> would use the same fetchExtendedChromInfoFromUCSC()...?
> 
> On a related note, is there a non-BSgenome package that has the chromosome 
> length / seqinfo information that doesn't require an internet connection 
> (other than to download the package)? BSgenome is too large to require of 
> users just for chromosome lengths. The org.db packages have chromosome 
> lengths, but only with respect to one genome version for that organism, and 
> from the documentation it isn't clear which version.
> 
> Thanks,
> Raymond Cavalcante
>         [[alternative HTML version deleted]]
> 
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