I can confirm that I am experiencing similar problems on OSX with several other packages at the moment (openssl and git2r), I know that Xcode just updated and am not sure if this is causing some of the problems (potentially some update with their command line tools?)...
install.packages('openssl', type=‘source’) ... ** testing if installed package can be loaded Error in dyn.load(file, DLLpath = DLLpath, ...) : unable to load shared object '/Library/Frameworks/R.framework/Versions/3.4/Resources/library/openssl/libs/openssl.so': dlopen(/Library/Frameworks/R.framework/Versions/3.4/Resources/library/openssl/libs/openssl.so, 6): Symbol not found: _ERR_free_strings Referenced from: /Library/Frameworks/R.framework/Versions/3.4/Resources/library/openssl/libs/openssl.so Expected in: flat namespace in /Library/Frameworks/R.framework/Versions/3.4/Resources/library/openssl/libs/openssl.so Error: loading failed Execution halted install.packages(‘git2r', type=‘source’) … ** testing if installed package can be loaded Error in dyn.load(file, DLLpath = DLLpath, ...) : unable to load shared object '/Library/Frameworks/R.framework/Versions/3.4/Resources/library/git2r/libs/git2r.so': dlopen(/Library/Frameworks/R.framework/Versions/3.4/Resources/library/git2r/libs/git2r.so, 6): Symbol not found: _SSL_library_init Referenced from: /Library/Frameworks/R.framework/Versions/3.4/Resources/library/git2r/libs/git2r.so Expected in: flat namespace in /Library/Frameworks/R.framework/Versions/3.4/Resources/library/git2r/libs/git2r.so Error: loading failed Execution halted sessionInfo() R Under development (unstable) (2016-05-23 r70660) Platform: x86_64-apple-darwin13.4.0 (64-bit) Running under: OS X 10.11.5 (El Capitan) locale: [1] en_GB.UTF-8/en_GB.UTF-8/en_GB.UTF-8/C/en_GB.UTF-8/en_GB.UTF-8 attached base packages: [1] stats graphics grDevices utils datasets methods base loaded via a namespace (and not attached): [1] tools_3.4.0 Kind Regards, Jason Serviss > On 24 May 2016, at 17:06, Aaron Lun <a...@wehi.edu.au> wrote: > > Dear Martin and List, > > I have a problem with linking to Rhtslib on Mac OSX when my R installation > directory differs from the package installation directory. Trying to load > csaw (Bioc release version) gives me: > >> require(csaw) > # ... whole lot of dependencies... > Loading required package: csaw > Error in dyn.load(file, DLLpath = DLLpath, ...) : > unable to load shared object > '/Users/lun01/Library/R/3.3/library/csaw/libs/csaw.so': > dlopen(/Users/lun01/Library/R/3.3/library/csaw/libs/csaw.so, 6): Library not > loaded: > /Library/Frameworks/R.framework/Versions/3.3/Resources/library/Rhtslib/lib/libhts.0.dylib > Referenced from: /Users/lun01/Library/R/3.3/library/csaw/libs/csaw.so > Reason: image not found > > ... which is because my Rhtslib shared library is sitting instead at > /Users/lun01/Library/R/3.3/library/Rhtslib/lib/libhts.0.dylib (along with all > my other non-recommended, non-base packages). I presume this linking failure > occurs because the Makevars file (which would normally indicate where the > shared library is living) doesn't get run when installing a prebuilt binary? > The same issue occurs with deepSNV, which is the other package that links to > Rhtslib. > > Any thoughts? I don't usually use Macs, so I don't know exactly what goes on > during package installation, or whether my setup (i.e., with different > package/R locations) is atypical or not. > > Aaron > >> sessionInfo() > R version 3.3.0 (2016-05-03) > Platform: x86_64-apple-darwin13.4.0 (64-bit) > Running under: OS X 10.10.5 (Yosemite) > > locale: > [1] en_GB.UTF-8/en_GB.UTF-8/en_GB.UTF-8/C/en_GB.UTF-8/en_GB.UTF-8 > > attached base packages: > [1] stats4 parallel stats graphics grDevices utils datasets > [8] methods base > > other attached packages: > [1] SummarizedExperiment_1.2.2 Biobase_2.32.0 > [3] GenomicRanges_1.24.0 GenomeInfoDb_1.8.1 > [5] IRanges_2.6.0 S4Vectors_0.10.1 > [7] BiocGenerics_0.18.0 BiocInstaller_1.22.2 > > loaded via a namespace (and not attached): > [1] AnnotationDbi_1.34.3 XVector_0.12.0 edgeR_3.14.0 > [4] GenomicAlignments_1.8.0 zlibbioc_1.18.0 BiocParallel_1.6.2 > [7] tools_3.3.0 DBI_0.4-1 Rhtslib_1.4.2 > [10] rtracklayer_1.32.0 bitops_1.0-6 RCurl_1.95-4.8 > [13] biomaRt_2.28.0 RSQLite_1.0.0 limma_3.28.5 > [16] GenomicFeatures_1.24.2 Biostrings_2.40.1 Rsamtools_1.24.0 > [19] XML_3.98-1.4 > ______________________________________________________________________ > > The information in this email is confidential and intend...{{dropped:4}} > > _______________________________________________ > Bioc-devel@r-project.org mailing list > https://stat.ethz.ch/mailman/listinfo/bioc-devel _______________________________________________ Bioc-devel@r-project.org mailing list https://stat.ethz.ch/mailman/listinfo/bioc-devel