Hi Thomas,

Sorry for not getting back to you earlier on this. Opening/closing
each file inside the loop (i.e. at the beginning/end of each iteration)
instead of opening all files before entering the loop would indeed
address the problem. I'll look into this and will let you know.

Cheers,
H.

On 02/15/2016 05:42 AM, Thomas Lin Pedersen wrote:
Hi (mostly Hervé)

I’m running into problems trying to run fasta.index() from Biostrings on a list 
of 4700 files, as the limit on open files are reached. Is it possible to 
continuously open and close the connections in the C code to circumvent this? I 
expect this problem also arises with readXStringSet..? I know dealing with such 
a high number of files in one chunk is probably an edge case, so I can 
understand if this is not something you wish to change the code for...

with best wishes

Thomas Lin Pedersen
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--
Hervé Pagès

Program in Computational Biology
Division of Public Health Sciences
Fred Hutchinson Cancer Research Center
1100 Fairview Ave. N, M1-B514
P.O. Box 19024
Seattle, WA 98109-1024

E-mail: hpa...@fredhutch.org
Phone:  (206) 667-5791
Fax:    (206) 667-1319

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