Hello all,
We have recently received a microarray experiment in the Nimblegen platform
where the intensity of the probe sets follow a bi-modal distribution. We
have been said from the facility that this is because of the dynamic range
of the Agilent scanner they use. We are concerned about the statistical
analysis with bioconductor as it is our understanding that these statistical
analyses are developed for normal or normal-like distribution. We appreciate
any information on this regard.
Thank you in advance for your help,
Miguel
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