Hi Paul, 

It is not possible to partially exclude members of a targeted user list 
criterion. User lists can only be modified using the AdWordsUserListService 
<https://developers.google.com/adwords/api/docs/reference/v201710/AdwordsUserListService>
 via 
the API. Similarly, to modify or set a campaign criterion you will need to 
use CampaignCriterionService 
<https://developers.google.com/adwords/api/docs/reference/v201710/CampaignCriterionService>
. 

For questions specific to AdWords API, you could use this forum. 
Unfortunately, we don't offer support via phone. If your questions are 
specific to AdWords product in general, you can either post that on the 
Advertisers 
community forum 
<https://www.en.advertisercommunity.com/t5/Google-AdWords/ct-p/Google_AdWords#> 
or 
use the Help button within the AdWords UI to call or email AdWords support. 

Thanks,
Sreelakshmi, AdWords API Team

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