Hi George,

If you wish to exclude audiences, you can either use the 
CampaignCriterionService 
<https://developers.google.com/adwords/api/docs/reference/v201710/CampaignCriterionService>
 to 
create a NegativeCampaignCriterion 
<https://developers.google.com/adwords/api/docs/reference/v201710/CampaignCriterionService.NegativeCampaignCriterion>
 of 
type CriterionUserList 
<https://developers.google.com/adwords/api/docs/reference/v201710/CampaignCriterionService.CriterionUserList>
 or 
the AdGroupCriterionService 
<https://developers.google.com/adwords/api/docs/reference/v201710/AdGroupCriterionService>
 to 
create a NegativeAdGroupCriterion 
<https://developers.google.com/adwords/api/docs/reference/v201710/AdGroupCriterionService.NegativeAdGroupCriterion>
 of 
type CriterionUserList 
<https://developers.google.com/adwords/api/docs/reference/v201710/AdGroupCriterionService.CriterionUserList>
. 

For the campaign level example, you may refer to the 
AddCampaignTargetingCriteria 
<https://developers.google.com/adwords/api/docs/samples/python/targeting#add-targeting-criteria-to-a-campaign>,
 
and to the AddKeywords 
<https://developers.google.com/adwords/api/docs/samples/python/basic-operations#add-keywords>
 example 
for the ad group level. Just replace the objects in the examples with the 
ones I mentioned as necessary. Let me know if you require more information.

Thanks and regards,
Peter
AdWords API Team

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