I haven't experienced this but I would proceed as follows:

- Check the logs on the webserver, look for all requests asking that URL. 
See whether the webserver responded 200.
- Don't forget to check the firewall which could have been denying access 
to certain users/ip addresses etc.
- If you use a Tracking Template look careful into that, make sure that it 
redirects to the final URL. I can imagine that Google will penalize after 
finding out requests are redirected to a different URL.

If HTTPS, are you using a well-known CA? Certain CAs are not trusted by all 
computers on the world. Note: I don't know which CAs Google trusts. BTW I 
don't think this is your issue, more a theoretical possibility.

Hope this helps.


On Thursday, November 24, 2016 at 9:23:17 AM UTC+1, Dorian Kind wrote:
>
> Hello,
>
> first of all I want to apologize, this is a question that is not strictly 
> about the Adwords API. However, in my experience I've been able to get more 
> valuable information in this group than in the Google Advertiser Community.
>
> So since a few months we've been increasingly experiencing the phenomenon 
> that lots of our ads are being disapproved with a reason of "Destination 
> not working" even though both final URL and final mobile URL work just 
> fine. This is especially notable when creating a large number of new ads 
> over the API, but sporadically also for ads that have been running for a 
> long time but are now being disapproved for the same reason. When 
> escalating to Adwords support, we are usually being told that while the 
> URLs they check do work for them, the only thing they can do is re-submit 
> the campaign for review, which usually doesn't help.
>
> Has anyone been experiencing the same?
>
> Many thanks for any feedback and best regards,
> Dorian
>

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