> I use Greylisting [1], and it's been really effective. No false  
> positives (so far), and 0 to 2 spam messages a day. All this for a  
> mild ~15 minute delay on genuine emails (but only for the first time).

sites like plan9.bell-labs.com tend not resend email with prec.  bulk
even when given a 45x error.

smtpd 451'd a couple messages within the last week due to dns errors.
the sender did not retry.   i assume that they would have not been resent
regardless of the text of the 451 message.

i did run greylisting for several days.  i found it cut down on spam
only about 20%.  those bots are getting smarter.

- erik


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